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. 2014 Dec 1;9(12):e113248. doi: 10.1371/journal.pone.0113248

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© 2014 Albrecht et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A) Comparison between predicted epitopes (predicted, in green) and epitopes correlated with rosette disruption ability (identified, in blue). Prediction of the localization of B-cell epitopes for the NTS-DBL1α^It4var60 domain was carried out and epitopes predicted to be surface exposed are marked in green. Epitopes that correlated with the ability to disrupt rosettes are marked in blue. B) A model of the NTS-DBL1α^It4var60 domain was generated based on the NTS-DBL1α^PAvarO crystal structure [18]. The mapped peptides targeted by antibodies that disrupted rosettes on FCR3S1.2 iRBC are highlighted in blue in the model. C) For comparison, the localization SD3-loop, previously identified as target of rosette disruptive antibodies (12) is highlighted in red and the RDSM motif, shown to induce strain-transcending antibodies [32], in orange.