Table 2. Peptides targeted by rosette disruptive antibodies in FCR3S1.2 iRBC.
Protein | Peptide | Sequence | Spearman r | p-value |
It4var60 | 009 | NEIELSARDVLENIG | 0.3768 | 0.0281 |
It4var60 | 097 | KRFDEGQKFECGNDK | 0.5132 | 0.0019 |
It4var60 | 105 | FECGNDKIIGNSDKY | 0.5268 | 0.0014 |
It4var60 | 125 | PRRRHICDQNLEFLD | 0.5264 | 0.0014 |
It4var60 | 293 | SVPTNLDYVPQFLRW | 0.3902 | 0.0225 |
It4var9 | 009 | TVNNLSATDVLEKIA | 0.4101 | 0.0160 |
It4var9 | 013 | LSATDVLEKIATGIY | 0.3722 | 0.0302 |
It4var9 | 017 | DVLEKIATGIYNQEK | 0.3465 | 0.0447 |
It4var9 | 097 | RFSNEGEAKCGSDKI | 0.3438 | 0.0465 |
It4var9 | 293 | TNVPTNLDYVPQFLR | 0.4443 | 0.0085 |
TM284 | 065 | NPCELKYQWHTNATR | 0.4592 | 0.0063 |
TM284 | 245 | EDWWNANRQEIWKAL | 0.3705 | 0.0310 |
TM284 | 293 | PPTYFDYVPQYLRWF | 0.3775 | 0.0278 |
TM284 | 309 | EWAEDFCTKRKHKLQ | 0.4333 | 0.0105 |
TM284 | 376 | IDNQQKEFEKQKKKY | 0.3418 | 0.0479 |
varO | 265 | WKALTCSAPYYADYF | 0.3879 | 0.0234 |
varO | 301 | APPTYLDYVPQFLRW | 0.3625 | 0.0351 |
It4var21 | 021 | EFGQKVHDEVHGEAK | 0.3854 | 0.0244 |
It4var21 | 053 | ETAFTVKSMQTESKY | 0.3434 | 0.0468 |
It4var21 | 181 | SFADIGDIIRGRDLY | 0.3835 | 0.0252 |
It4var21 | 273 | SSYFRATCSDTGQGP | 0.5312 | 0.012 |
3D7var4 | 061 | PFSAYRPNYGNPCEL | 0.4328 | 0.0106 |
3D7var4 | 065 | YRPNYGNPCELDYRF | 0.436 | 0.0102 |
3D7var4 | 173 | YTGYGIYKSGICTSL | 0.4376 | 0.0096 |
3D7var4 | 301 | VLTNLDYVPQFLRWF | 0.3449 | 0.0457 |
3D7var4 | 309 | PQFLRWFEEWAEEFC | 0.4099 | 0.0160 |
3D7var4 | 341 | SKKLYCSHNGYDCTK | 0.5318 | 0.0012 |
3D7var4 | 345 | YCSHNGYDCTKTIRN | 0.5906 | 0.0002 |
C1388/UAS22 | 065 | NTKLQTLTLHQVREY | 0.4302 | 0.0111 |
C1388/UAS22 | 101 | IFSKNIRNGNTILFD | 0.3608 | 0.0361 |
C1413/UAS31 | 081 | AWWKAHRDQVWKAIT | 0.4200 | 0.0134 |
C1413/UAS31 | 101 | KVDYFIKNSDGSRGF | 0.3627 | 0.0350 |
C1429/UAS29 | 148 | DQVPTYFDYVPQYLR | 0.4214 | 0.0131 |
List of peptides, recognized on the peptide array, with a positive correlation with the ability of the plasma sample to disrupt FCR3S1.2 rosettes. Peptides indicated in bold are conserved between different parasite sequences and are further described in Figure S2.