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(A) ACD25 mAb or control (IgG isotype control) treated mice exhibit deterioration in FS parameter. (B) ACD25 mAb or control (IgG isotype control) treated mice exhibit significant increase in LVESA after 4 weeks compared to baseline. p based on Two-way repeated measures ANOVA; *p<0.02 and **p<0.002 based on 2-tail paired test.
