Table 3. Comparison of left ventricular remodeling and function in ACD25 or IgG injected mice by 2-dimensional echocardiography 1 day after MI (baseline) and 4 weeks after first echo.

	ACD25(n = 15)	IgG (n = 12)	p 1(repeated measures ANOVA)
LVEDD, mm
Baseline	3.79±0.13	3.7±0.1
4 weeks	4.34±0.17	4.2±0.13
P 2(paired t-test)	0.0174	0.0035	0.97
LVESD, mm
Baseline	2.843±0.15	2.852±0.14
4 weeks	3.46±0.19	3.46±0.17
P 2(paired t-test)	0.0175	0.0094	0.99
LVEDA, mm2
Baseline	12.4±0.63	11.81±0.5
4 weeks	15.4±1.09	14.92±0.7
P 2(paired t-test)	0.025	0.0016	0.92
LVESA, mm2
Baseline	6.95±0.58	6.463±0.6
4 weeks	9.633±0.81	9.42±0.7
P 2(paired t-test)	0.0121	0.0051	0.813
FS, %
Baseline	25.62±1.89	23.18±2.34
4 weeks	20.87 ± 1.98	18.779±1.92
P 2(paired t-test)	0.094	0.16	0.895
EF, %
Baseline	50.51±3.072	46.39±3.912
4 weeks	42.047±3.316	38.61±3.44
P 2(paired t-test)	0.0715	0.092	0.88
LVEDV, mm3
Baseline	63.2±5.03	58.94±3.9
4 weeks	88.15±8.8	81.97±5.9
P 2(paired t-test)	0.004	0.009	0.85
LVESV, mm3
Baseline	32.73±4.06	32.23±3.603
4 weeks	52.67±6.9	51.61±6.025
P 2(paired t-test)	0.003	0.011	0.99
EF, %
Baseline	50.51±3.072	46.39±3.912
4 weeks	42.047±3.316	38.61±3.44
P 2(paired t-test)	0.009	0.05	0.88

1. p in the right column reflect comparison of the differences between treatment and control groups over time. p based on 2-way repeated measures ANOVA.

2. p in the left columns are for the differences between baseline and 4-week measurements, based on paired t-test.

LVEDD  =  left ventricle end diastolic diameter; LVESD  =  left ventricle end systolic diameter; LVEDA  =  left ventricle end diastolic area; LVESA  =  left ventricle end systolic area; FS  =  fractional shortening  =  [(LVDD -LVSD)/LVDD]x100; FAC  =  fractional area change  =  [(LVEDA-LVESA)/LVEDA]X100; LVEDV  =  left ventricle end diastolic volume; LVESV  =  left ventricle end systolic volum; EF  =  ejection fraction.