Table 3. Comparison of left ventricular remodeling and function in ACD25 or IgG injected mice by 2-dimensional echocardiography 1 day after MI (baseline) and 4 weeks after first echo.
ACD25(n = 15) | IgG (n = 12) | p 1(repeated measures ANOVA) | |
LVEDD, mm | |||
Baseline | 3.79±0.13 | 3.7±0.1 | |
4 weeks | 4.34±0.17 | 4.2±0.13 | |
P 2(paired t-test) | 0.0174 | 0.0035 | 0.97 |
LVESD, mm | |||
Baseline | 2.843±0.15 | 2.852±0.14 | |
4 weeks | 3.46±0.19 | 3.46±0.17 | |
P 2(paired t-test) | 0.0175 | 0.0094 | 0.99 |
LVEDA, mm2 | |||
Baseline | 12.4±0.63 | 11.81±0.5 | |
4 weeks | 15.4±1.09 | 14.92±0.7 | |
P 2(paired t-test) | 0.025 | 0.0016 | 0.92 |
LVESA, mm2 | |||
Baseline | 6.95±0.58 | 6.463±0.6 | |
4 weeks | 9.633±0.81 | 9.42±0.7 | |
P 2(paired t-test) | 0.0121 | 0.0051 | 0.813 |
FS, % | |||
Baseline | 25.62±1.89 | 23.18±2.34 | |
4 weeks | 20.87 ± 1.98 | 18.779±1.92 | |
P 2(paired t-test) | 0.094 | 0.16 | 0.895 |
EF, % | |||
Baseline | 50.51±3.072 | 46.39±3.912 | |
4 weeks | 42.047±3.316 | 38.61±3.44 | |
P 2(paired t-test) | 0.0715 | 0.092 | 0.88 |
LVEDV, mm3 | |||
Baseline | 63.2±5.03 | 58.94±3.9 | |
4 weeks | 88.15±8.8 | 81.97±5.9 | |
P 2(paired t-test) | 0.004 | 0.009 | 0.85 |
LVESV, mm3 | |||
Baseline | 32.73±4.06 | 32.23±3.603 | |
4 weeks | 52.67±6.9 | 51.61±6.025 | |
P 2(paired t-test) | 0.003 | 0.011 | 0.99 |
EF, % | |||
Baseline | 50.51±3.072 | 46.39±3.912 | |
4 weeks | 42.047±3.316 | 38.61±3.44 | |
P 2(paired t-test) | 0.009 | 0.05 | 0.88 |
1. p in the right column reflect comparison of the differences between treatment and control groups over time. p based on 2-way repeated measures ANOVA.
2. p in the left columns are for the differences between baseline and 4-week measurements, based on paired t-test.
LVEDD = left ventricle end diastolic diameter; LVESD = left ventricle end systolic diameter; LVEDA = left ventricle end diastolic area; LVESA = left ventricle end systolic area; FS = fractional shortening = [(LVDD -LVSD)/LVDD]x100; FAC = fractional area change = [(LVEDA-LVESA)/LVEDA]X100; LVEDV = left ventricle end diastolic volume; LVESV = left ventricle end systolic volum; EF = ejection fraction.