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. Author manuscript; available in PMC: 2015 Jul 31.
Published in final edited form as: Cell. 2014 Jul 31;158(3):564–578. doi: 10.1016/j.cell.2014.05.045

Figure 2. Stromal Hsf1 status alters tumor progression and histology in human breast xenografts.

Figure 2

MCF7 breast cancer cells alone or mixed with WT or Hsf1 null primary MEFs were injected subcutaneously into NOD-scid mice. The experiment was repeated twice, with 4 mice per group in each experiment. (A) The mean tumor volume (total 8 per treatment group) is shown. The distribution of individual measurements is shown in the lower panels, in scatter plots for days 22 and 38 post injection. Error bars, SEM. *p<0.05, **p<0.01. (B) Mice were sacrificed when tumor burden reached size limit and the tumors were excised, fixed and stained with hematoxylin & eosin (H&E, upper panels) or Masson’s trichrome stain (lower panels). All images collected at the same magnification. Scale bar = 50μm. See also Figure S2.