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. 2014 Dec 1;9(12):e113604. doi: 10.1371/journal.pone.0113604

Figure 2. Cryptoporus volvatus extract acts at an early and late stages in the replication cycle.

Figure 2

(A) Time course analysis of the extract inhibitory effects on influenza A virus replication. MDCK cells were infected with A/WSN (H1N1) at an MOI of 1, and then at different time points, treated with the normal saline control, extract (5 mg/ml), or ribavirin (20 µm). Virus titer at 9 hpi was determined. (B) The Cryptoporus volvatus extract did not inactivate influenza virus directly. Incubating the A/WSN (H1N1) virus with different concentrations of the extract at 37°C for 1 h or 3 h, then virus titer was determined in MDCK cells. Data are representative of three independent experiments (mean ±SEM). Statistical significance was analyzed by One-way ANOVA. *P<0.05; **P<0.01.