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. 2014 Dec 1;9(12):e113784. doi: 10.1371/journal.pone.0113784

Figure 3. Cox5a promoter is hypermethylated in the skeletal muscle from high-fat diet (HFD)-induced insulin resistant rats.

Figure 3

(A) Real-time PCR quantification of Cox5a mRNA expression in skeletal muscle from control and HFD groups. (B–C) Western blot of Cox5a protein level (n = 7/group). (D) Cox5a methylation levels are negatively correlated with Cox5a mRNA expression levels. (E) Cox5a methylation levels are negatively correlated with Cox5a protein levels. (F) Complex IV activity. (G) Cellular ATP content. Mean±SD. (n = 7/group. Student's t test, *p<0.05 vs control.)