Table 1.
Preoperative Features
| Variable | Mild (n = 388) | Overt (n = 1049) | p value |
|---|---|---|---|
| DEMOGRAPHICS | |||
| Age | 60±1 | 61± 0 | 0.24 |
| Female gender | 309 (79.8) | 796 (77.3) | 0.30 |
| SYMPTOMS | |||
| Kidney stones | 12 (3.1) | 13 (1.3) | 0.02 |
| Fatigue | 46 (11.9) | 84 (8.1) | 0.03 |
| Bone disease+ | 119 (40.1) | 176 (43.0) | 0.49 |
| EXAM | |||
| BMI (kg/m2) | 30.3± 0.4 | 31.6± 0.3 | 0.02 |
| Systolic BP (mmHg) | 129±1 | 133±1 | <0.01 |
| Diastolic BP (mmHg) | 75±1 | 78±1 | 0.01 |
| LABS | |||
| Ca (mg/dL) | 10.6 ± 0.0 | 11.2 ± 0.0 | <0.01 |
| Phos (mg/dL) | 3.2 ± 0.1 | 2.8± 0.1 | <0.01 |
| PTH (pg/mL) | 75 ± 2 | 145 ± 4 | <0.01 |
| Urinary Ca (mg/dL) | 297 ± 10 | 335 ±9 | <0.01 |
| Alk Phos (U/L) | 89±3 | 101 ±2 | <0.01 |
| Vit D (ng/mL) | 35±1 | 30±1 | <0.01 |
| Creatinine (mg/dL) | 0.99± 0.0 | 1.04 ± 0.0 | 0.15 |
| GFR (mL/min) | 90± 2 | 89± 1 | 0.63 |
| IMAGING | |||
| + Sestamibi* | 242 (62.4) | 826 (78.6) | <0.01 |
| BMD worst T score# | −1.9 ± 0.1 | −1.8 ± 0.2 | 0.67 |
Data are represented as the mean ± standard error of the mean for continuous variables or as the number in each category with the percentage in parentheses for categorical variables
Bone disease indicates either osteopenia or osteoporosis measured by bone mineral density scan
Indicates a sestamibi scan that localizes a suspected parathyroid adenoma
The lowest T score from any site on preoperative bone mineral density scan
BMI = body mass index; Kg = kilograms; m2 = meters squared; BP = blood pressure; Ca = calcium; Phos = phosphorous; PTH = parathyroid hormone; Urinary Ca = 24 hour urinary calcium; Alk Phos = alkaline phosphatase; Vit D = 25-hydroxyvitamin D; mg = milligrams; dL = deciliter; GFR = glomerular filtration rate; mL = milliliters; min = minute; BMD = bone mineral density