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. 2014 Dec 1;9(12):e113858. doi: 10.1371/journal.pone.0113858

Table 3. Multivariate analysis to identify factors predicting poor overall survival and disease-free survival of patients with hepatocellular carcinoma after curative hepatectomy.* .

Hazard Ratio 95% CI P
Overall Survival
Diabetes mellitus 1.482 1.044–2.104 0.028
AFP (≥400 ng/mL) 1.603 1.108–2.319 0.012
Albumin (<35 g/L) 1.634 1.035–2.577 0.035
GGT (≥50 U/L) 1.891 1.245–2.872 0.003
Tumor capsule (Incomplete) 1.553 1.073–2.247 0.020
Macrovascular invasion 2.333 1.561–3.486 <0.001
Tumor size (≥10 cm) 1.112 1.012–1.223 0.027
Tumor number (≥3) 2.431 1.596–3.702 <0.001
Differentiation degree (Poorly) 2.380 1.266–4.475 <0.001
Disease-free survival
Diabetes mellitus 0.878 0.624–1.237 0.458
AFP ( ≥400 ng/mL) 1.399 1.011–1.937 0.043
Albumin (<35 g/L) 1.425 0.944–2.151 0.092
GGT (≥50 U/L) 1.450 1.040–2.020 0.028
Tumor capsule (Incomplete) 1.563 1.136–2.146 0.006
Macrovascular invasion 1.638 1.124–2.388 0.010
Tumor size (≥10 cm) 1.098 1.000–1.205 0.049
Tumor number (≥3) 2.138 1.453–3.147 <0.001
Differentiation degree (Poorly) 1.814 1.102–2.984 0.019

*Calculated using data from all patients in the original cohort (without propensity score matching).

Abbreviations: AFP, alpha-fetoprotein; CI, confidence interval, GGT, γ-glutamyl transferase.