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. 2014 Sep 30;22(12):2142–2154. doi: 10.1038/mt.2014.157

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Copyright © 2014 American Society of Gene & Cell Therapy

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Assessment of functional growth inhibitory activity (GIA) induced by mixed-modality AMA1 immunization regimens. (a) In vitro GIA of purified IgG was assessed at 10 mg/ml against 3D7 clone P. falciparum parasites. Individual data and medians are shown for each group at d0 (baseline), and then 4 weeks following all booster vaccinations (d84 or d140). Responses >20% are typically regarded as positive. (b) Relationship between GIA and anti-3D7 AMA1 serum IgG concentrations measured by enzyme-linked immunosorbent assay (ELISA). Nonlinear regression curve is also shown (n = 67). The EC₅₀ (level of anti-3D7 AMA1 response in this ELISA assay that gives 50% GIA, indicated by the dotted line) was 69.7 µg/ml, (95% CI: 50.2–97.0).