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. 2014 Dec 1;9(12):e114006. doi: 10.1371/journal.pone.0114006

Figure 4. Induction of humoral anti-HBc response in BALB/c mice by HBc VLPs formulated with different adjuvants.

Figure 4

A – total anti-HBc titers, B – ratio of anti-HBc IgG2a/IgG1 isotype titers. The HBc VLPs were adjuvanted with Silica, Alhydrogel, CFA/IFA, IFA or diluted in PBS. Mice were bled after intraperitoneal (i.p.) and subcutaneous (s.c.) immunisation at day 42 after the first injection. The results represent anti-HBc titers or ratios of the IgG2a/IgG1 titers as the means from five mice ± standard deviation (SD).