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. 2014 Dec 1;9(12):e114006. doi: 10.1371/journal.pone.0114006

Figure 5. Induction of the humoral anti-HBc response in BALB/c mice by HBc VLPs formulated with different adjuvants in combination with MPL.

Figure 5

A – total anti-HBc titers, B – ratio of anti-HBc IgG2a/IgG1 isotype titers. HBc VLPs were adjuvanted with Silica and Alhydrogel in the presence or absence of MPL or adjuvanted with MPL alone. Mice were bled after subcutaneous (s.c.) injection on day 10. The results represent anti-HBc titers or the ratios of the IgG2a/IgG1 titers as the means from five mice ± standard deviation (SD).