Table I.
Creatinine clearance and urinary calcium to creatinine ratio by diagnosis, age group, and transfusion status.
| Diagnosis | N | Creatinine clearance (ml/min/m2)
|
Calcium to creatinine ratio
|
||
|---|---|---|---|---|---|
| Mean ± SD | Range | Mean ± SD | Range | ||
| All Patients, N = 217 | |||||
| β-thalassemia (≥8/year)★ | 163 | 140·6 ± 50·0 | 32·47–423·5 | 0·18 ± 0·10 | 0·01–0·57 |
| β-thalassaemia (<8/year)† | 17 | 191·0 ± 73·8 | 77·8–324·1 | 0·12 ± 0·07 | 0·01–0·30 |
| β-thalassaemia (none)‡ | 8 | 178·0 ± 68·7 | 93·2–287·3 | 0·13 ± 0·11 | 0·03–0·34 |
| Hb H disease | 8 | 150·6 ± 52·3 | 68·3–235·4 | 0·09 ± 0·06 | 0·04–0·22 |
| Hb H-Constant Spring | 6 | 141·3 ± 46·9 | 70·78–214·3 | 0·16 ± 0·15 | 0·01–0·37 |
| E-β-thalassaemia (≥8/year) ★ | 3 | 187·0 ± 98·6 | 128·0–300·9 | 0·14 ± 0·08 | 0·06–0·21 |
| E-β-thalassaemia (<8/year)† | 8 | 181·3 ± 93·5 | 89·2–349·8 | 0·12 ± 0·11 | 0·01–0·31 |
| E-β-thalassaemia (none) ‡ | 2 | 166·9 ± 48·2 | 132·9–201·0 | 0·09 ± 0·09 | 0·03–0·16 |
| Homozy. α-thalassaemia | 1 | 140·1 | – | 0·26 | – |
| Children (<18 years), N = 85 | |||||
| β-thalassemia (≥8/year)★ | 57 | 148·9 ± 41·6 | 75·0–244·8 | 0·17 ± 0·12 | 0·01–0·57 |
| β-thalassaemia (<8/year)† | 4 | 235·1 ± 64·2 | 180·4–311·5 | 0·10 ± 0·03 | 0·06–0·13 |
| β-thalassaemia (none) ‡ | 6 | 166·6 ± 61·1 | 93·2–241·8 | 0·16 ± 0·12 | 0·05–0·34 |
| Hb H disease | 7 | 150·1 ± 56·4 | 68·3–235·4 | 0·09 ± 0·06 | 0·04–0·22 |
| Hb H-Constant Spring | 4 | 157·2 ± 40·7 | 118·7–214·2 | 0·18 ± 0·17 | 0·01–0·37 |
| E-β-thalassaemia (≥8/year) ★ | 1 | 300·9 | – | 0·14 | – |
| E-β-thalassaemia (<8/year)† | 4 | 245·6 ± 89·6 | 155·6–349·8 | 0·09 ± 0·15 | 0·01–0·31 |
| E-β-thalassaemia (none) ‡ | 2 | 166·9 ± 48·2 | 132·9–201·0 | 0·09 ± 0·09 | 0·03–0·16 |
| Adults (≥18 years), N = 131 | |||||
| β-thalassemia (≥8/year)★ | 106 | 136·1 ± 53·7 | 32·5–423·5 | 0·18 ± 0·10 | 0·02–0·47 |
| β-thalassaemia (<8/year)† | 13 | 177·4 ± 73·5 | 77·8–324·1 | 0·13 ± 0·08 | 0·01–0·30 |
| β-thalassaemia (none) ‡ | 2 | 212·3 ± 106·1 | 137·2–287·3 | 0·04 ± 0·01 | 0·03–0·05 |
| Hb H disease | 1 | 154·0 | – | 0·12 | – |
| Hb H-Constant Spring | 2 | 109·5 ± 54·8 | 70·8–148·3 | 0·11 ± 0·13 | 0·02–0·20 |
| E-β-thalassaemia (≥8/year) ★ | 2 | 130·1 ± 3·0 | 128·0–132·2 | 0·14 ± 0·11 | 0·06–0·21 |
| E-β-thalassaemia (<8/year)† | 4 | 116·9 ± 36·5 | 89·2–168·4 | 0·16 ± 0·07 | 0·10–0·24 |
| Homozy. α-thalassaemia | 1 | 140·1 | – | 0·26 | – |
★
≥8 transfusions per year.
†
<8 transfusions per year.
‡
Not transfused in past year.