Table III.
Multivariate regression models of creatinine clearance, urinary calcium to creatinine ratio (UCa:UCr), urinary albumin, and total urinary protein by chelation group.
| Model and significant predictors★ | All chelators†
|
No deferasirox‡
|
||
|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | |
| Model: High creatinine clearance (vs. normal) | ||||
| Regular transfusion status (yes vs. no) | 0·39 | 0·17–0·88 | 0·42 | 0·18–0·94 |
| Serum transferrin receptor | 1·03 | 1·01–1·05 | 1·03 | 1·01–1·05 |
| Dietary calcium intake (mg) | 1·00 | 1·00–1·01 | ||
| Model: High UCa:UCr (vs. normal) | ||||
| Regular transfusion status (yes vs. no) | 3·72 | 1·24–11·2 | 3·54 | 1·17–10·7 |
| Serum transferrin receptor | 0·98 | 0·95–0·99 | ||
| Model: Detectable albumin (vs. not detectable) | ||||
| Serum transferrin receptor | 1·04 | 1·01–1·06 | 1·03 | 1·01–1·06 |
| Serum ferritin | 0·81 | 0·67–0·98 | ||
| Failure to thrive (yes vs. no) | 0·48 | 0·24–0·95 | ||
| β | P | β | P | |
|
|
||||
| Model: Total protein (log-transformed) | ||||
| Serum transferrin receptor | 0·015 | <0·0001 | 0·016 | <0·0001 |
★
All models controlled for age and gender.
†
All patients, regardless of iron chelator, were included.
‡
Patient receiving deferasirox (N = 17) were excluded from the analyses.
OR, odds ratio; 95% CI, 95% confidence interval