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Dual role of FSH in establishing the EGFR signaling axis in the ovarian follicle. FSH induces GCs to express both LHCGR, which enables them to release EGFR ligands in response to the preovulatory LH surge, and EGFR, which enables them to respond to these ligands. The two-step FSH-driven remodeling of the late-follicular environment may ensure an efficient and coordinated response to ovulatory signals.
