Fig. 5.

Effect of cytisine pretreatment on counterregulatory hormone release during insulin-induced recurrent hypoglycemia. Plasma epinephrine (A), norepinephrine (B), glucagon (C), and corticosterone (D) responses during hypoglycemic clamp in RS (maximal response group), RH (hypoglycemia-associated autonomic failure group), RC, and CRH. The results are summarized from 3 independent experiments (n = 9) and are presented as means ± SE. *P ≤ 0.05; **P ≤ 0.002 RH vs. RS; ^xP ≤ 0.05 and ^xxP ≤ 0.002, RH vs. CRH.