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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Neuropharmacology. 2014 Sep 6;89:11–18. doi: 10.1016/j.neuropharm.2014.08.014

Figure 3.

Figure 3

LY293558 protects against soman-induced, long-term increases in anxiety-like behavior, as measured by the open field and acoustic startle response (ASR) tests. A. At 30 and 90 days after soman exposure, soman-exposed rats that did not receive anticonvulsant treatment spent significantly less time in the center of the open field, compared to control rats, while soman+LY293558 treated rats did not differ from the controls. B and C. At 30 and 90 days after soman exposure, the amplitude of the startle response to 110 dB (B) and 120 dB (C) startle stimuli was significantly increased in the soman rats, but not in the soman+LY293558 rats, compared to the control group. **p < 0.01, ***p < 0.001; n = 10 per group (One-Way ANOVA with Dunnett’s T post hoc).