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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Sep 15;24(21):5098–5101. doi: 10.1016/j.bmcl.2014.08.066

Table 2.

Potency
(EC50)		 Solubility Caco-2
(A->B)
10−6 cm s−1 		Caco-2
(B->A)
10−6 cm s−1 		Efflux
ratio		 Human
Metabolic
Potential
(T1/2)		 Mouse
Metabolic
Potential
(T1/2)		 Plasma
Stability
(Calc T1/2)
graphic file with name nihms627115t5.jpg 1.68 uM 31.3 uM 73.4 26.0 0.35 64 min 16 min 63.5 min
graphic file with name nihms627115t6.jpg 2.19 uM >500 uM 60.7 14.0 0.23 >180 min 43 min >1000 min
graphic file with name nihms627115t7.jpg 3.23 uM 31.3 uM 66.3 17.1 0.26 31 min 22 min 131.2 min
graphic file with name nihms627115t8.jpg 2.54 uM 250 uM 51.7 10.5 0.20 > 180 min 20 min >1000 min