Table 1.
Class Comparison Analysis: Differentially expressed genes in control vs IPA/NO vs DEA/NO
| Parametric p-value |
FDR | Control | IPA/NO aspirin |
DEA/NO aspirin |
Symbol | Name |
|---|---|---|---|---|---|---|
| 5.00E-07 | 0.00044 | 158.29 | 182.26 | 357.41 | MIR21 | microRNA 21 |
| 1.20E-06 | 0.00044 | 134.74 | 374.85 | 168.1 | HSPA1A | heat shock 70kDa protein 1A |
| 1.60E-06 | 0.00044 | 178.03 | 440.57 | 229.01 | HSPA1B | heat shock 70kDa protein 1B |
| 2.60E-06 | 0.000557 | 691.18 | 307.05 | 532.37 | CTH | cystathionase (cystathionine gamma-lyase) |
| 5.40E-06 | 0.000946 | 550.46 | 259.01 | 346.26 | GTPBP2 | GTP binding protein 2 |
| 6.70E-06 | 0.00108 | 69.32 | 37.01 | 52.14 | SYT1 | synaptotagmin I |
| 7.70E-06 | 0.00114 | 276.85 | 470.1 | 427.43 | MASTL | microtubule associated serine/threonine kinase- like |
| 9.00E-06 | 0.00122 | 129.41 | 71.47 | 103.75 | ZNF643 | zinc finger protein 643 |
| 1.31E-05 | 0.00146 | 47.71 | 80.12 | 76.08 | KATNAL1 | katanin p60 subunit A-like 1 |
| 1.85E-05 | 0.00178 | 113.37 | 183.65 | 130.16 | ARRB1 | arrestin, beta 1 |
| 2.53E-05 | 0.00212 | 60.59 | 125.97 | 70.11 | MIR27B | microRNA 27b |
| 3.31E-05 | 0.00251 | 27.11 | 48.35 | 26.25 | ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
| 3.39E-05 | 0.00251 | 43 | 81.96 | 62.54 | CSNK1G1 | casein kinase 1, gamma 1 |
| 3.73E-05 | 0.00255 | 141.68 | 255.44 | 216.93 | CDCA3 | cell division cycle associated 3 |
| 3.84E-05 | 0.00255 | 310.44 | 136.8 | 270.54 | DDIT3 | DNA-damage-inducible transcript 3 |
| 4.50E-05 | 0.00289 | 1031.9 | 1113.08 | 1691.28 | MMP1 | matrix metallopeptidase 1 (interstitial collagenase) |
| 4.79E-05 | 0.00298 | 26.13 | 37.57 | 49.8 | C5orf54 | chromosome 5 open reading frame 54 |
| 5.81E-05 | 0.00334 | 79.86 | 77.24 | 132.14 | MIR100 | microRNA 100 |
| 5.89E-05 | 0.00334 | 488.23 | 274.58 | 356.01 | UFM1 | ubiquitin-fold modifier 1 |
| 6.35E-05 | 0.0034 | 1770.85 | 826.61 | 894.51 | TXNIP | thioredoxin interacting protein |
| 6.84E-05 | 0.0034 | 289.23 | 156.84 | 189.52 | MXD1 | MAX dimerization protein 1 |
| 7.23E-05 | 0.0034 | 54 | 111.12 | 75.49 | TGFBR3 | transforming growth factor, beta receptor III |
| 8.39E-05 | 0.00385 | 145.67 | 216.93 | 105.31 | SNORD14E | small nucleolar RNA, C/D box 14E |
| 8.80E-05 | 0.00394 | 97.67 | 135.92 | 148.06 | FAM36A | family with sequence similarity 36, member A |
| 0.0001013 | 0.00438 | 16.26 | 41.79 | 25.53 | KLRC4-KLRK1 | KLRC4-KLRK1 readthrough |
| 0.0001033 | 0.00438 | 186.29 | 219.91 | 320.13 | CPA4 | carboxypeptidase A4 |
| 0.0001045 | 0.00438 | 819.14 | 396.85 | 530.51 | SLFN5 | schlafen family member 5 |
| 0.0001127 | 0.00456 | 44.67 | 70.34 | 49.72 | CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| 0.0001186 | 0.00466 | 151.53 | 241.16 | 184.47 | SOS1 | son of sevenless homolog 1 (Drosophila) |
| 0.0001275 | 0.00491 | 125.65 | 56.4 | 94.63 | SLC16A1 | solute carrier family 16, member 1 (monocarboxylic acid transporter 1) |
| 0.0001711 | 0.00611 | 37.19 | 56.42 | 33.29 | KLRC4 | killer cell lectin-like receptor subfamily C, member 4 |
| 0.0001782 | 0.00624 | 32.9 | 55.11 | 35.37 | CYP1A1 | cytochrome P450, family 1, subfamily A, |
| polypeptide 1 | ||||||
| 0.0002038 | 0.00687 | 95.02 | 163.46 | 105.71 | TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) |
| 0.0002069 | 0.00687 | 145.58 | 217.73 | 265.69 | HIST1H2AK | histone cluster 1, H2ak |
| 0.0002325 | 0.00747 | 30.48 | 42 | 53.64 | MIR15A | microRNA 15a |
| 0.0002495 | 0.00788 | 1318.22 | 731.84 | 1096.74 | ASNS | asparagine synthetase (glutamine-hydrolyzing) |
| 0.0002608 | 0.00811 | 55.23 | 70.89 | 63.14 | TAS2R31 | taste receptor, type 2, member 31 |
| 0.0002742 | 0.00826 | 321.72 | 184.71 | 240.24 | TRIML2 | tripartite motif family-like 2 |
| 0.0003194 | 0.00947 | 40.67 | 19.71 | 27.67 | OLAH | oleoyl-ACP hydrolase |
| 0.0003389 | 0.0096 | 143.33 | 262.36 | 199.65 | FAM102B | family with sequence similarity 102, member B |
| 0.0003919 | 0.0103 | 110.28 | 73.16 | 72.47 | ANKRD11 | ankyrin repeat domain 11 |
| 0.0004377 | 0.011 | 191.39 | 349.72 | 290.22 | GMNN | geminin, DNA replication inhibitor |
| 0.0004424 | 0.011 | 722.45 | 438.41 | 647.09 | CASP4 | caspase 4, apoptosis-related cysteine peptidase |
| 0.0004676 | 0.011 | 470.21 | 848.73 | 689.63 | HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) |
| 0.0004948 | 0.0111 | 123.33 | 272.9 | 202.96 | FAM111B | family with sequence similarity 111, member B |
| 0.0005848 | 0.0122 | 80.38 | 103.67 | 96.64 | ZNF699 | zinc finger protein 699 |
| 0.0007473 | 0.0147 | 83.91 | 164 | 155.71 | CENPI | centromere protein I |
| 0.0007983 | 0.0151 | 442.05 | 561.76 | 586.57 | CDK1 | cyclin-dependent kinase 1 |
| 0.0008052 | 0.0151 | 41.62 | 17.11 | 27.66 | C12orf39 | chromosome 12 open reading frame 39 |
| 0.0008272 | 0.0152 | 276.03 | 131.2 | 174.89 | GDF15 | growth differentiation factor 15 |
| 0.0009894 | 0.0177 | 129.32 | 183.21 | 159.07 | PLK4 | polo-like kinase 4 |
| 0.0010473 | 0.0182 | 190.18 | 247.79 | 233.37 | GPR125 | G protein-coupled receptor 125 |
| 0.0010698 | 0.0184 | 101.54 | 51.49 | 55.33 | UFM1 | ubiquitin-fold modifier 1 |
| 0.0011657 | 0.0197 | 36.87 | 36.84 | 26.34 | SNORA2B | small nucleolar RNA, H/ACA box 2B |
| 0.0011932 | 0.02 | 25.76 | 18.03 | 16.58 | TNFSF18 | tumor necrosis factor (ligand) superfamily, member 18 |
| 0.0013126 | 0.0213 | 78.71 | 152.05 | 121.04 | ORC1 | origin recognition complex, subunit 1 |
| 0.0013441 | 0.0216 | 32.29 | 50.95 | 43.56 | DSEL | dermatan sulfate epimerase-like |
| 0.0013774 | 0.0219 | 81.09 | 110.77 | 97.89 | SERTAD4 | SERTA domain containing 4 |
| 0.0014926 | 0.0233 | 161.4 | 206.74 | 119.33 | SNORD12C | small nucleolar RNA, C/D box 12C |
| 0.0015019 | 0.0233 | 184.74 | 180.78 | 124.2 | EIF4A2 | eukaryotic translation initiation factor 4A2 |
| 0.001705 | 0.0246 | 35.9 | 54.09 | 43.2 | CDRT1 | CMT1A duplicated region transcript 1 |
| 0.0018118 | 0.0255 | 140.04 | 220.86 | 208.61 | MMS22L | MMS22-like, DNA repair protein |
| 0.0018598 | 0.026 | 362.63 | 592.15 | 516.16 | SKP2 | S-phase kinase-associated protein 2 (p45) |
| 0.0019382 | 0.0267 | 33.46 | 57.16 | 41.69 | PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) |
| 0.0022295 | 0.0296 | 148.85 | 208.38 | 179.76 | TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 |
| 0.002407 | 0.0309 | 122.27 | 209.4 | 183.63 | ESCO2 | establishment of cohesion 1 homolog 2 (S. cerevisiae) |
| 0.0024782 | 0.0316 | 299.78 | 478.11 | 464.06 | WDHD1 | WD repeat and HMG-box DNA binding protein 1 |
| 0.0026491 | 0.0333 | 81.77 | 114.13 | 75.33 | S100A4 | S100 calcium binding protein A4 |
| 0.0027266 | 0.0338 | 53.48 | 91.61 | 72.04 | SLC38A4 | solute carrier family 38, member 4 |
| 0.002739 | 0.0338 | 62.92 | 40.49 | 47.37 | SLC5A4 | solute carrier family 5 (low affinity glucose cotransporter), member 4 |
| 0.0028887 | 0.0349 | 834.01 | 538.55 | 516.07 | SNORD15B | small nucleolar RNA, C/D box 15B |
| 0.0030393 | 0.0353 | 66.68 | 88.7 | 91.01 | LRRCC1 | leucine rich repeat and coiled-coil domain containing 1 |
| 0.0034645 | 0.0384 | 69.46 | 107.45 | 91.53 | BMP4 | bone morphogenetic protein 4 |
| 0.0034884 | 0.0384 | 919.74 | 1180.48 | 863.52 | SNORD30 | small nucleolar RNA, C/D box 30 |
| 0.0039179 | 0.0412 | 241.05 | 341.9 | 337.09 | HSPB11 | heat shock protein family B (small), member 11 |
| 0.0039544 | 0.0412 | 121.73 | 189.61 | 186.52 | CCNE2 | cyclin E2 |
| 0.003966 | 0.0412 | 100.5 | 161.62 | 144.65 | HIST1H3A | histone cluster 1, H3a |
| 0.0045144 | 0.044 | 127.21 | 82.32 | 100.69 | U2AF1L4 | U2 small nuclear RNA auxiliary factor 1-like 4 |
| 0.0045306 | 0.044 | 89.42 | 133.28 | 131.31 | NMU | neuromedin U |
| 0.0047269 | 0.0451 | 79.93 | 37.91 | 57.23 | IL24 | interleukin 24 |
| 0.00486 | 0.0456 | 76.16 | 97.2 | 108.87 | HSD17B7P2 | hydroxysteroid (17-beta) dehydrogenase 7 pseudogene 2 |
| 0.0053066 | 0.0478 | 42.77 | 27.46 | 30.84 | RAB7A | RAB7A, member RAS oncogene family |
| 0.0055138 | 0.0488 | 34.57 | 49.41 | 39.87 | OVOS | ovostatin |
| 0.0059611 | 0.052 | 83.56 | 108.25 | 85.13 | SNORD4B | small nucleolar RNA, C/D box 4B |
| 0.0061285 | 0.0527 | 52.16 | 32.28 | 28.13 | NOL7 | nucleolar protein 7, 27kDa |
| 0.0068846 | 0.0562 | 69.47 | 97.5 | 98.3 | FANCB | Fanconi anemia, complementation group B |
| 0.0070186 | 0.0568 | 23.73 | 22.28 | 26.93 | MC3R | melanocortin 3 receptor |
| 0.0071233 | 0.0574 | 301.44 | 496.32 | 409.56 | CLSPN | claspin |
| 0.0081236 | 0.0616 | 195.84 | 213.56 | 150.45 | SNORA62 | small nucleolar RNA, H/ACA box 62 |
| 0.0088207 | 0.0646 | 73.42 | 109.89 | 61.49 | FABP4 | fatty acid binding protein 4, adipocyte |
| 0.0092606 | 0.0661 | 49.63 | 34.77 | 31.84 | LLPH | LLP homolog, long-term synaptic facilitation (Aplysia) |
| 0.0097317 | 0.0679 | 118.67 | 147.13 | 149.61 | SCAI | suppressor of cancer cell invasion |
| 0.0098834 | 0.0685 | 32.32 | 50.91 | 45.37 | GPR137C | G protein-coupled receptor 137C |