Table 2.
Class Comparison Analysis: Differentially expressed genes in aspirin vs Control vs DEA/NO vs DEA/NO- aspirin vs IPA/NO vs IPA/NO-aspirin
| Parametric p-value |
FDR | Aspirin | Control | DEA/NO | DEA/NO aspirin |
IPA/NO | IPA/NO aspirin |
Symbol | Name |
|---|---|---|---|---|---|---|---|---|---|
| < 1e-07 | < 1e-07 | 157.71 | 134.74 | 180.66 | 168.1 | 138.36 | 374.85 | HSPA1A | heat shock 70kDa protein 1A |
| 1.00E-07 | 3.85E-05 | 217.58 | 178.76 | 253.16 | 228.54 | 196.13 | 441.1 | HSPA1B | heat shock 70kDa protein 1B |
| 2.00E-07 | 6.42E-05 | 129.96 | 158.29 | 212.72 | 357.41 | 336.45 | 182.26 | MIR21 | microRNA 21 |
| 3.70E-06 | 0.000732 | 2063.12 | 1770.85 | 1458.8 | 894.51 | 1869.4 | 826.61 | TXNIP | thioredoxin interacting protein |
| 3.80E-06 | 0.000732 | 520.53 | 550.46 | 407.47 | 346.26 | 479.93 | 259.01 | GTPBP2 | GTP binding protein 2 |
| 4.50E-06 | 0.000788 | 648.79 | 691.18 | 598.54 | 532.37 | 628.32 | 307.05 | CTH | cystathionase (cystathionine gamma- lyase) |
| 6.18E-05 | 0.00791 | 817.15 | 819.14 | 695 | 530.51 | 772.75 | 396.85 | SLFN5 | schlafen family member 5 |
| 7.29E-05 | 0.00791 | 34.78 | 28.38 | 58.9 | 22.48 | 27.46 | 32.25 | FLJ16171 | FLJ16171 protein |
| 7.36E-05 | 0.00791 | 1230.98 | 1318.22 | 1113.71 | 1096.74 | 1284.57 | 731.84 | ASNS | asparagine synthetase (glutamine- hydrolyzing) |
| 7.59E-05 | 0.00791 | 123.22 | 113.37 | 113.62 | 130.16 | 132.96 | 183.65 | ARRB1 | arrestin, beta 1 |
| 9.90E-05 | 0.00954 | 55.15 | 54 | 71.05 | 75.49 | 69.29 | 111.12 | TGFBR3 | transforming growth factor, beta receptor III |
| 0.0001065 | 0.00977 | 344.03 | 310.44 | 239.07 | 270.54 | 401.34 | 136.8 | DDIT3 | DNA-damage- inducible transcript 3 |
| 0.000115 | 0.0101 | 60.95 | 69.32 | 64.71 | 52.14 | 63.82 | 37.01 | SYT1 | synaptotagmin I |
| 0.0001325 | 0.0109 | 109.96 | 125.65 | 116.2 | 94.63 | 103.04 | 56.4 | SLC16A1 | solute carrier family 16, member 1 (monocarboxylic acid transporter 1) |
| 0.0001818 | 0.014 | 275.67 | 289.23 | 173.28 | 189.52 | 241.75 | 156.84 | MXD1 | MAX dimerization protein 1 |
| 0.000231 | 0.0167 | 174.29 | 186.29 | 176.02 | 320.13 | 172.25 | 219.91 | CPA4 | carboxypeptidase A4 |
| 0.0002426 | 0.0167 | 30.09 | 27.11 | 32.82 | 26.25 | 25.56 | 48.35 | ID2 | inhibitor of DNA binding 2, dominant negative helix-loop- helix protein |
| 0.0003971 | 0.0225 | 116.22 | 145.67 | 199.52 | 105.31 | 103.5 | 216.93 | SNORD14E | small nucleolar RNA, C/D box 14E |
| 0.0004856 | 0.026 | 113.64 | 97.67 | 192.34 | 148.06 | 165.15 | 135.92 | FAM36A | family with sequence similarity 36, member A |
| 0.0005102 | 0.0262 | 46.31 | 44.67 | 50.76 | 49.72 | 42.76 | 70.34 | CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| 0.0006235 | 0.0308 | 28.1 | 37.96 | 22.55 | 30.14 | 28.77 | 28.42 | CXCL2 | chemokine (C-X-C motif) ligand 2 |
| 0.0007044 | 0.0335 | 343.39 | 321.72 | 293.69 | 240.24 | 288.81 | 184.71 | TRIML2 | tripartite motif family- like 2 |
| 0.0007155 | 0.0335 | 163.87 | 184.74 | 198.14 | 124.2 | 103.51 | 180.78 | EIF4A2 | eukaryotic translation initiation factor 4A2 |
| 0.0007603 | 0.0335 | 242.43 | 276.03 | 160.58 | 174.89 | 269.25 | 131.2 | GDF15 | growth differentiation factor 15 |
| 0.0007652 | 0.0335 | 46.17 | 43 | 67.92 | 62.54 | 49.22 | 81.96 | CSNK1G1 | casein kinase 1, gamma 1 |
| 0.0009788 | 0.0355 | 471.51 | 488.23 | 502.42 | 356.01 | 449.83 | 274.58 | UFM1 | ubiquitin-fold modifier 1 |
| 0.0009939 | 0.0355 | 79.45 | 89.42 | 95.62 | 131.31 | 83.43 | 133.28 | NMU | neuromedin U |
| 0.001165 | 0.0401 | 101.31 | 95.02 | 114.88 | 105.71 | 110.36 | 163.46 | TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) |
| 0.0016524 | 0.0506 | 662.91 | 722.45 | 664.69 | 647.09 | 696.38 | 438.41 | CASP4 | caspase 4, apoptosis- related cysteine peptidase |
| 0.0018161 | 0.0538 | 149.69 | 141.68 | 216.36 | 216.93 | 156.4 | 255.44 | CDCA3 | cell division cycle associated 3 |
| 0.0019214 | 0.0553 | 137.44 | 123.33 | 219.24 | 202.96 | 130.18 | 272.9 | FAM111B | family with sequence similarity 111, member B |
| 0.0019549 | 0.0554 | 98.22 | 83.91 | 121.46 | 155.71 | 95.21 | 164 | CENPI | centromere protein I |
| 0.0021586 | 0.0562 | 29.63 | 26.13 | 32.67 | 49.8 | 39.36 | 37.57 | C5orf54 | chromosome 5 open reading frame 54 |
| 0.0022755 | 0.0585 | 53.28 | 47.71 | 62.76 | 76.08 | 49.37 | 80.12 | KATNAL1 | katanin p60 subunit A- like 1 |
| 0.0026234 | 0.0647 | 32.01 | 30.48 | 56.94 | 53.64 | 50.44 | 42 | MIR15A | microRNA 15a |
| 0.0026532 | 0.0647 | 37.97 | 41.62 | 37.8 | 27.66 | 38.07 | 17.11 | C12orf39 | chromosome 12 open reading frame 39 |
| 0.002932 | 0.0689 | 87.1 | 79.86 | 121.93 | 132.14 | 150.85 | 77.24 | MIR100 | microRNA 100 |
| 0.0033175 | 0.0726 | 211.91 | 191.39 | 272.01 | 290.22 | 212.27 | 349.72 | GMNN | geminin, DNA replication inhibitor |
| 0.0033797 | 0.0732 | 151.81 | 151.53 | 145.21 | 184.47 | 157.86 | 241.16 | SOS1 | son of sevenless homolog 1 (Drosophila) |
| 0.0034924 | 0.0748 | 98.82 | 78.71 | 148.21 | 121.04 | 86.69 | 152.05 | ORC1 | origin recognition complex, subunit 1 |
| 0.0035543 | 0.0753 | 87.19 | 79.93 | 88.71 | 57.23 | 78.89 | 37.91 | IL24 | interleukin 24 |
| 0.0036557 | 0.0757 | 133.48 | 129.41 | 135.11 | 103.75 | 114.46 | 71.47 | ZNF643 | zinc finger protein 643 |
| 0.0040681 | 0.08 | 19.66 | 28.53 | 13.67 | 19.35 | 23.01 | 19.85 | RNF185 | ring finger protein 185 |
| 0.0042597 | 0.0822 | 34.63 | 37.19 | 35.04 | 33.29 | 48.72 | 56.42 | KLRC4 | killer cell lectin-like receptor subfamily C, member 4 |
| 0.0046958 | 0.0892 | 190.64 | 145.58 | 233.96 | 265.69 | 261.36 | 217.73 | HIST1H2AK | histone cluster 1, H2ak |
| 0.0050098 | 0.0919 | 145.49 | 143.33 | 192.08 | 199.65 | 143.97 | 262.36 | FAM102B | family with sequence similarity 102, member B |
| 0.0055921 | 0.0971 | 33.08 | 32.32 | 39.31 | 45.37 | 32.02 | 50.91 | GPR137C | G protein-coupled receptor 137C |
| 0.0063822 | 0.109 | 87.31 | 60.59 | 112.04 | 70.11 | 85.08 | 125.97 | MIR27B | microRNA 27b |
| 0.0068906 | 0.115 | 320.62 | 276.85 | 414.25 | 427.43 | 314.83 | 470.1 | MASTL | microtubule associated serine/threonine kinase-like |
| 0.0069605 | 0.115 | 26.56 | 16.26 | 25.57 | 25.53 | 38.79 | 41.79 | KLRC4- KLRK1 |
KLRC4-KLRK1 readthrough |
| 0.0070361 | 0.115 | 1166.34 | 1031.9 | 1010.08 | 1691.28 | 1032.54 | 1113.08 | MMP1 | matrix metallopeptidase 1 (interstitial collagenase) |
| 0.0073541 | 0.116 | 120.93 | 127.21 | 85.92 | 100.69 | 121.26 | 82.32 | U2AF1L4 | U2 small nuclear RNA auxiliary factor 1-like 4 |
| 0.0091362 | 0.131 | 416.41 | 362.63 | 588.42 | 516.16 | 370.17 | 592.15 | SKP2 | S-phase kinase- associated protein 2 (p45) |
| 0.0093547 | 0.133 | 71.86 | 76.16 | 123.41 | 108.87 | 101.19 | 97.2 | HSD17B7P2 | hydroxysteroid (17- beta) dehydrogenase 7 pseudogene 2 |
| 0.0098301 | 0.134 | 38.32 | 32.29 | 38.33 | 43.56 | 31.37 | 50.95 | DSEL | dermatan sulfate epimerase-like |
| 0.009931 | 0.134 | 67.62 | 62.92 | 55.15 | 47.37 | 60.1 | 40.49 | SLC5A4 | solute carrier family 5 (low affinity glucose cotransporter), member 4 |