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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Pain. 2014 Jun 3;155(12):2476–2485. doi: 10.1016/j.pain.2014.05.030

Figure 2.

Figure 2

C fibers from sickle mice are sensitized to cold stimuli. (A) C fibers isolated from sickle mice were activated by cold stimulation at a similar proportion compared to HbAA control C fibers. (B) Cold-activated C fibers from sickle mice had a significantly lower cold detection threshold, meaning they responded to cold stimulation at warmer temperatures than HbAA controls (P < 0.05). (C) There was no significant difference in the number of action potentials fired by cold-responsive C fibers from SCD or HbAA mice in response to cold stimulation (P = 0.1848).