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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Pain. 2014 Jun 3;155(12):2476–2485. doi: 10.1016/j.pain.2014.05.030

Figure 3.

Figure 3

Cold aversion increases with age in sickle mice. Aged mice are on average 18.4 (± 0.4) months; younger adult mice are on average 7.9 (± 0.3) months. Mouse behavior was tested using a thermally-controlled floor with one side at 30°C and the other at 23°C, and cold aversion was measured as the percent of time spent on the colder plate during a 5 minute test. (A) Aged male HbSS mice portrayed heightened cold aversion compared with younger adult HbSS mice (*** P < 0.001). Additionally, the aged HbSS mice showed much greater cold aversion than their aged control counterparts (**** P < 0.0001). Aged male HbAA mice (controls) show no difference in cold aversion or thermal preference compared to younger adult HbAA mice (P > 0.05). (B) There were no differences in the number of crosses performed by older control or HbSS mice (P > 0.05).