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Growth inhibition of selected analogs on HNSCC cell lines 686LN, CAL33, FADU and OSC19
| Compd# | 686LN IC50 (μM) |
CAL33 IC50 (μM) |
FADU IC50 (μM) |
OSC19 IC50 (μM) |
|---|---|---|---|---|
| 11a | 37.5 ± 11.1 | 29.4 ± 5.9 | 18.8 ± 5.3 | 17.0 ± 4.6 |
| 11b | 49.3a | 19.7 ± 0.5 | 11.0 ± 0.1 | 12.8 ± 0.9 |
| 11c | 2.4 ± 0.6 | 1.2 ± 0.3 | 1.9 ± 0.1 | 3.2 ± 0.4 |
| 19a | 18.0 ± 10.4 | 12.9 ± 0.9 | 30.9 ± 14.9 | 11.2a |
| 19g | 37.8a | 11.1a | 17.9a | 19.0a |
| 19h | 43.7 ± 0.7 | >50 | 27.4 ± 13.3 | >50 |
| 6 | >5 | 1.3 ± 0.4 | 2.4 ± 0.6 | 7.7 ± 4.7 |
Results from a single experiment.
