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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Semin Immunol. 2014 Oct 7;26(6):486–496. doi: 10.1016/j.smim.2014.09.002

Table 2.

Cyclic di-nucleotide cyclases and phosphodiesterase of M. tuberculosis

Cyclic di-GMP
Gene number/name Function Domain composition
Rv1354c Cyclase- phosphodiesterase (bi- functional protein) graphic file with name nihms628861t1.jpg
Rv1357 Phosphodiesterase graphic file with name nihms628861t2.jpg
Cyclic di-AMP
Rv3586
disA
dacA		 Cyclase graphic file with name nihms628861t3.jpg
Rv2837c
NrnA
cnpB		 Phosphodiesterase graphic file with name nihms628861t4.jpg

Domain composition of cyclic di-nucleotide cyclases and phosphodiesterases are shown as predicted using the SSDB Motif (http://www.kegg.jp/kegg/ssdb/) and conserved domain (http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi?db+cdd) databases. Gene nomenclature is according to the M. tuberculosis H37Rv genome annotation. Major functional domains: GGDEF, c-di-GMP cyclase; EAL, c-di-GMP phosphodiesterase; DisA-N, c-di-AMP cyclase; DHH, c-di-AMP phosphodiesterase.