Figure 3.

β-Cell homeostasis in RIP-HGF TG mice with IRS2 deficiency. A, Representative photomicrographs of mouse pancreatic sections stained for insulin (brown) and counterstained with hematoxylin from WT, TG, KO, and TG/KO mice at 12 weeks of age. B–D, Quantification of β-cell mass (B), islet number per pancreatic area (C), and singlet, doublet, and ductal insulin-positive cells per pancreatic area (D). Results are means ± SEM and were obtained from 5 to 7 mice per genotype. *, P < .05 vs the other 3 groups of mice; #, P < .05 vs WT and TG/KO mice; ∧, P < .05 vs WT and TG mice.