Figure 7.

Schematic representation of HGF action in β-cells in the absence or presence of IRS2. HGF action in an adult β-cell under basal conditions (A), in the absence of IRS2 (B), and when overexpressed in the absence of IRS2 (C). Phosphorylation of PI3K/AKT/FoxO1 by overexpressed HGF in the absence of IRS2 leads to an increased nuclear presence of Pdx-1, p27 down-regulation, increased β-cell replication, and survival. An increase in the size of the font/boxes indicates up-regulation/activation of that protein.