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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Semin Immunol. 2014 Oct 11;26(6):559–577. doi: 10.1016/j.smim.2014.09.003

Figure 1. Complex interactions between resident and recruited innate leukocytes lead to bacterial dissemination and acquisition of antigen by DC for T cell priming.

Figure 1

Multiple cell types are initially infected including macrophages, PMNs and DCs. Both apoptotic and necrotic types of cell death can occur following primary M. tuberculosis infection. Apoptosis is associated with control of infection and can lead to acquisition of antigen by APC by the process of efferocytosis. In contrast, necrosis facilitates dispersal of bacteria and re-infection of other cell types. DC, whether they have acquired antigen via efferocytosis or by infection, traffic to the lung draining LN where they have a vital role in T cell priming.