Table 2.

Genes on the X chromosome associated with POI. Superscripts correspond to the literature reference relating each gene with POI

Gene	Locus	Other diseases associated
CHM [21]	Xq21.1-q21.3	Choroideremia
DIAPH2 [21]	Xq21.33	−
DACH2 [21]	Xq21.3	Allan-Herndon-Dudley syndrome
POF1B [21]	Xq21.2	−
XPNPEP2 [21]	Xq25	Angioedema
NXF5 [22]	Xq22.1	Pelizaeus Merzbache disease, intelectual disability
FMR1 [26]	Xq27.3	X fragile syndrome
FMR2 [35]	Xq28	XE fragile syndrome, intellectual disability
XIST [10]	Xq13.2	X inactivation, familial skewed, testicular cancer
CENP1 [20]	Xq22.1	Scleroderma, liver disease
PGRMC1 [36]	Xq22-q24	Placental choriocarcinoma, sphenoid sinusitis
AR [37]	Xq12	Androgenin sensivity syndrome
FOXO4 [38]	Xq13.1	Malignant spindle cell melanoma, X-linked dystonia-parkinsonism
AGTR2 [19]	Xq22-23	Cerebrovascular accident, Conn’s syndrome
BHLHB9 [3]	Xq22.1	Colon cancer, Alzheimer’s disease
BMP15 [39]	Xp11.2	Turner syndrome
ZFX [10]	Xp22.1-21.3	Retinoschisis, Turner syndrome
SHOX [40]	Xp22.33	Leri weill dyschondrosteosis, Turner syndrome