Table 4.
Novel candidate POI genes identified by the genome-wide approach. Superscripts correspond to the literature reference relating each gene with POI
| Gene | Initials | Locus |
|---|---|---|
| PTHB1 [81] | Parathiroid-Hormone Responsive B1 | 7p14 |
| BCKDHB [82] | Branched Chain Keto Acid Dehydrogenase E1, Beta Polypeptide | 6q14.1 |
| ACSL6 [83] | Acyl-CoA Synthetase Long-Chain Family Member 6 | 5q31 |
| HK3 [84] | Hexokinase 3 | 5q35.2 |
| BRSK1 [84] | BR Serine/Threonine Kinase 1 | 19q13.4 |
| ADAMTS19 [85] | ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 19 | 5q23.3 |
| LAMC1 [86] | Laminin, Gamma 1 (Formerly LAMB2) | 1q31 |
| PCMT1 [87] | Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase | 6q24-q25 |
| DNAH5 [88] | Dynein, Axonemal, Heavy Chain 5 | 5p15.2 |
| NAIP [88] | NLR Family, Apoptosis Inhibitory Protein | 5q13.2 |
| DUSP22 [88] | Dual SpecificityPhosphatase 22 | 6p25.3 |
| NUPR1 [88] | Nuclear Protein, TranscriptionalRegulator, 1 | 16p11.2 |
| AKT1 [88] | V-Akt Murine Thymoma Viral Oncogene Homolog 1 | 14q32.32 |
| UTP14A [89] | U3 Small NucleolarRibonucleoprotein, Homolog A | Xq26.1 |
| PCDH19 [89] | Protocadherin 19 | Xq13.3 |
| VCX [89] | Variable Charge, X-Linked | Xp22 |
| STS [89] | Steroid Sulfatase (Microsomal), Isozyme S | Xp22.32 |
| BCORL1 [89] | BCL6 Corepressor-Like 1 | Xq26.1 |
| TSPAN7 [89] | Tetraspanin 7 | Xp11.4 |
| AIFM1 [89] | Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 | Xq26.1 |
| SYCE1 [90, 91] | Synaptonemal Complex Central Element Protein 1 | 10q26.3 |
| CPEB1 [91] | Cytoplasmic Polyadenylation Element Binding Protein 1 | 15q25.2 |
| CCBE1 [91] | Collagen And Calcium Binding EGF Domains 1 | 18q21.32 |
| PMAIP1 [91] | Phorbol-12-Myristate-13-Acetate-Induced Protein 1 | 18q21.32 |
| CTNNA3 [91] | Catenin (Cadherin-Associated Protein), Alpha 3 | 10q21.3 |
| ANKRD22 [91] | AnkyrinRepeatDomain 22 | 10q23.31 |
| STAMBPL1 [91] | STAM BindingProtein-Like 1 | 10q23.31 |
| HSD3B2 [91] | Hydroxy-Delta-5-Steroid Dehydrogenase, 3-Betaand Steroid Delta-Isomerase2 | 1p12 |
| HAO2 [91] | Hydroxyacid Oxidase 2 (Long Chain) | 1p12 |
| CYP2E1 [90] | Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 | 10q26.3 |
| NRXN1 [90] | Neurexin 1 | 2p16.3 |
| PARK2 [90] | Parkin RBR E3 UbiquitinProtein Ligase | 6q26 |
| CARD11 [90] | Caspase Recruitment Domain Family, Member 11 | 7p22.2 |
| DHFR [74] | DihydrofolateReductase | 5q14.1 |
| NR2F1 [74] | Nuclear Receptor Subfamily 2, Group F, Member 1 | 5q14 |
| MEF2C [74] | MADS Box Transcription Enhancer Factor 2, Polypeptide C | 5q14.3 |
| CCNH [74] | Cyclin H | 5q13.3-q14 |
| SSBP2 [74] | Single-Stranded DNA Binding Protein 2 | 5q14.1 |
| CSPG2 [74] | Chondroitin Sulfate Proteoglycan 2 | 5q14.2 |
| EIF4ENIF1 [75] | Eukaryotic Translation Initiation Factor 4E Nuclear Import Factor 1 | 22q12.2 |
| DLX5 [76] | Distal-LessHomeobox 5 | 7q21.3 |
| DLX6 [76] | Distal-Less Homeobox 6 | 7q21.3 |
| DSS1 [76] | Split Hand/Foot Malformation (Ectrodactyly) Type 1 | 7q21.3 |
| STAG3 [77] | Stromal Antigen 3 | 7q22.1 |