Chemoreduction regimen and doses for intraocular retinoblastoma

Day 1: Vincristine + Etoposide + Carboplatin

Day 2: Etoposide

Standard dose (3 weekly, 6 cycles): Vincristine 1.5 mg/m22 (0.05 mg/kg for children <36 months of age and maximum dose <2 mg), Etoposide 150 mg/m (5 mg/kg for children <36 months of age), Carboplatin 560 mg/m2 (18.6 mg/kg for children <36 months of age)

High-dose (3 weekly, 6–12 cycles): Vincristine 0.025 mg/kg, Etoposide 12 mg/kg, Carboplatin 28 mg/kg