Table 2.
Comparison between clinico-pathological features of loss of heterozygosity-high and loss of heterozygosity-low in colorectal cancer, n (%).
| Features | Total | LOH-high | LOH-low | P |
| Number of cases | 207 | 93 (44.9) | 114 (55.1) | |
| Age (yr) | 66.2±12.4 | 67.2±12.4 | 65.4±12.3 | 0.2921 |
| Gender (male/female) | 139/68 | 61/32 | 78/36 | 0.7782 |
| Location of tumor | ||||
| Right colon | 37 (17.9) | 16 (17.2) | 21 (18.4) | 0.5443 |
| Left colon | 85 (41.1) | 42 (45.2) | 43 (37.7) | |
| Rectum | 85 (41.1) | 35 (37.6) | 50 (43.9) | |
| TNM stage | ||||
| I | 25 (12.1) | 7 (7.5) | 18 (15.8) | <0.0014 |
| II | 73 (35.3) | 22 (23.7) | 51 (44.7) | |
| III | 68 (32.9) | 37 (39.8) | 31 (27.2) | |
| IV | 41 (19.8) | 27 (29.0) | 14 (12.3) | |
| Invasive pattern | ||||
| Expanding | 52 (25.1) | 20 (21.5) | 32 (28.1) | 0.2862 |
| Infiltrative | 155 (74.9) | 73 (78.5) | 82 (71.9) | |
| Grade | ||||
| Well-differentiated | 5 (2.4) | 2 (2.2) | 3 (2.6) | 0.2633 |
| Moderate differentiated | 182 (87.9) | 81 (87.0) | 101 (88.6) | |
| Poorly differentiated | 20 (9.7) | 10 (10.8) | 10 (8.8) | |
| Lymphovascular invasion | ||||
| Yes | 48 (23.2) | 27 (56.3) | 21 (43.7) | 0.1022 |
| No | 159 (76.8) | 66 (41.5) | 93 (58.5) | |
| Mucin production | ||||
| Yes | 29 (14.0) | 9 (9.7) | 20 (17.5) | 0.1552 |
| No | 178 (86.0) | 84 (90.3) | 94 (82.5) |
1
Student t test,
2
Fisher exact test,
3
Pearson χ2 test,
4
χ2 test with linear-by-linear association.