Table 2.
Association analysis of the IL-10 –1082 promoter polymorphism with the risk of ESCC and GCA development.
| A/A | A/G+G/G | aOR (95%CI)3 | |
| Overall | |||
| Normal | 267 (60.3) | 176 (39.7) | |
| ESCC | 117 (57.6) | 86 (42.4) | 0.92 (0.76–1.11) |
| GCA | 93 (61.2) | 59 (38.8) | 0.95 (0.61–1.46) |
| Nonsmoker1 | |||
| Normal | 181 (62.4) | 109 (37.6) | |
| ESCC | 52 (61.2) | 33 (38.8) | 0.89 (0.67–1.18) |
| GCA | 26 (59.1) | 18 (40.9) | 0.79 (0.39–1.63) |
| Smoker | |||
| Normal | 80 (55.6) | 64 (44.4) | |
| ESCC | 61 (57.5) | 45 (42.5) | 1.01 (0.77–1.33) |
| GCA | 54 (61.4) | 34 (38.6) | 1.11 (0.61–2.02) |
| Negative family history2 | |||
| Normal | 168 (60.2) | 111 (39.8) | |
| ESCC | 48 (56.5) | 37 (43.5) | 0.92 (0.70-1.20) |
| GCA | 30 (63.8) | 17 (36.2) | 1.10 (0.54-2.22) |
| Positive family history | |||
| Normal | 99 (60.4) | 65 (39.6) | |
| ESCC | 56 (60.2) | 37 (39.8) | 0.96 (0.71–1.29) |
| GCA | 40 (54.0) | 34 (46.0) | 0.71 (0.37–1.36) |
ESCC: esophageal squamous cell carcinoma. GCA: gastric cardiac adenocarcinoma. 1,2information of smoking status and family history was available from a subset of subjects;
3
The age and sex adjusted odds ratio of the A/G+G/G genotype against the A/A genotype.