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. 2005 Mar 7;11(9):1382–1386. doi: 10.3748/wjg.v11.i9.1382

Table 1.

Inhibitory effect of Gefitinib or/and CDDP on mouse implanted H22 tumors (mean).

Groups n
Weight of tumor (g)
IR (%)
Exp 1 Exp 2 Exp 1 Exp 2 Exp 1 Exp 2
Lecithin control 14 14 1.39±0.70 1.42±0.41 0 0
NS control 13 14 1.49±0.80 1.41±0.46 0 0
CDDP d1-5 14 13 0.68±0.27 0.81±0.30 54 43
CDDP d6-10 12 14 0.80±0.25 0.96±0.32 46 32
Gefitinib d1-10 14 0.88±0.28 41
Gefitinib d1-5 14 0.99±0.39 30
Gefitinib d1-10+CDDP d1-5 13 0.66±0.24 56
Gefitinib d1-10+CDDP d6-10 14 1.11±0.41b 26b
Gefitinib d1-5+CDDP d1-5 14 0.63±0.35 56
CDDP d1-5→Gefitinib d6-10 13 0.55±0.25b 61b
Gefitinib d1-5→CDDP d6-10 13 0.90±0.30 36
b

P<0.01 vs Gefitinib d1-10+CDDP d1-5, or Gefitinib d1-5→CDDP d6-10 group, IR: inhibitory rate, CDDP: cisplatin, Exp 1: the first experiment, Exp 2: the second experiment.