Table 1.
Clinicopathologic characteristics of colorectal cancer with expression of COX-2.
| Variable | n | COX-2 positive n (%) | COX-2 negative n (%) |
| Sex | |||
| Male | 73 | 50 (68.5) | 23 (31.5) |
| Female | 55 | 37 (67.3) | 18 (32.7) |
| Age (yr) | 54±12 | 56±15 | |
| Histological differentiation | |||
| Well | 26 | 17 (65.4) | 9 (34.6) |
| Moderate | 57 | 40 (70.2) | 17 (29.8) |
| Poor | 45 | 30 (66.7) | 15 (33.3) |
| Depth of invasion | |||
| T1-T2 | 81 | 48 (59.3) | 33 (40.7) |
| T3-T4 | 47 | 39 (83.0) | 8 (17.0)a |
| Metastasis | |||
| Present | 50 | 42 (84.0) | 8 (16.0) |
| Absent | 78 | 45 (57.7) | 33 (42.3)a |
| Dukes stage | |||
| I | 37 | 15 (40.5) | 22 (59.5) |
| II | 41 | 28 (68.3) | 13 (31.7) |
| III+IV | 50 | 44 (88.0) | 6 (12.0)a |
| VEGF expression | |||
| Positive | 49 | 40 (81.6) | 9 (18.4) |
| Negative | 79 | 47 (59.5) | 32 (40.5)a |
| MMP-2 expression | |||
| Positive | 88 | 70 (79.6) | 18 (20.4) |
| Negative | 40 | 17 (42.5) | 23 (57.5)a |
a
P<0.05 vs positive.