Table 2.
Mean pharmacokinetic parameters of 125I-C-1027 measured by TCA-RA method at three doses in mice (n = 6).
| Parameters | Unit |
Doses (mg/kg) |
P | ||
| 10 | 50 | 100 | |||
| A | ng/mL | 34.62 | 142.98 | 277.02 | |
| a | /h | 9.61 | 9.64 | 4.92 | |
| B | ng/mL | 3.31 | 18.1 | 26.02 | |
| b | /h | 0.22 | 0.2 | 0.18 | |
| V(d) | L/kg | 0.26 | 0.31 | 0.33 | >0.05 |
| T1/2a | h | 0.07 | 0.07 | 0.14 | |
| T1/2b | h | 3.1 | 3.4 | 3.9 | >0.05 |
| K21 | /h | 1.04 | 1.26 | 0.58 | |
| K10 | /h | 2.06 | 1.55 | 1.49 | >0.05 |
| K12 | /h | 6.73 | 7.03 | 3.02 | |
| AUC | ng.h/mL | 18.41 | 103.69 | 202.74 | |
| CL(S) | L/(kg.h) | 0.54 | 0.48 | 0.49 | >0.05 |
V(d): Apparent distribution volume; T1/2: Half-life; K: Elimination rate constant; AUC: Area under curve; CL(S): Clearance.