Dynamics of anti-preS1 responses of BALB/c mice immunized with CI, CII, CIII or 21-47*6 with Freund’s adjuvant (FA) at wk 0 and 5 (arrows) or immunized with CII and 21-47*6 without adjuvant at weeks 0, 5 and 16 (arrows). Mice were immunized by i.m. injection of proteins: 20 μg CI, CII, CIII or 50 μg 21-47*6.