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. Author manuscript; available in PMC: 2015 Nov 6.
Published in final edited form as: Cell Rep. 2014 Oct 30;9(3):1089–1098. doi: 10.1016/j.celrep.2014.09.053

Figure 2. Effect of Anti-B7x Monoclonal Antibodies on Tumor Growth.

Figure 2

(A) BALB/c mice were iv injected with B7x/CT26 then with anti-B7x mAbs 12D11 and 1H3 or mouse IgG. After sacrifice, tumor nodules in lungs were counted. Data were pooled from three independent experiments (n= 9 or 10). (B) BALB/c females were injected with B7x/4T1 in the mammary fat pad. Mice were ip treated with mAb 1H3. Tumor volumes were measured every two or three days after tumor injection. After mice were sacrificed, tumor weights were measured and tumor nodules on lungs were counted (n=10). *p<0.05. (C) BALB/c mice were iv injected with CT26 cells expressing human B7x (hB7x/CT26) and then injected ip with mAb 1H3 or control IgG. After sacrificing the mice, tumor nodules in the lungs were counted (n=9). Results were pooled from two independent experiments. (D) Several human cancers were stained with 1H3 or IgG control using immunohistochemistry. Bars 50µm.