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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Pediatr Clin North Am. 2015 Feb;62(1):47–60. doi: 10.1016/j.pcl.2014.09.004

Figure 2. Pathogenesis of ALL.

Figure 2

Several inherited variants associated with susceptibility to ALL have been identified by genome– wide association studies and studies of familial ALL. Within hematopoietic cells, in addition to a sentinel event such as a chromosomal translocation, a multitude of secondary genetic events contribute to leukemic transformation.