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. 2014 Sep 18;142(2):395–402. doi: 10.1093/toxsci/kfu185

FIG. 4.

FIG. 4.

mtDNA damage detectable in rotenone animals treated to PD endpoint. A, Blood collected after rats were treated with rotenone to endpoint, exhibited greater levels of mtDNA damage than vehicle-treated animals (black bar, 0.48 lesions ± 0.03/10 kb; *P < .0001). B, Skeletal muscle also showed increased mtDNA damage in rotenone-treated animals relative to vehicle (black bar, 0.27 lesions ± 0.02/10 kb; *P < .0001). Levels of blood mtDNA damage are statistically higher than muscle mtDNA damage (P < .0001). n = 7 (vehicle) and n = 10 (rotenone) treated rats were used for blood DNA damage analysis. n = 5 (vehicle) and n = 5 (rotenone) treated rats were used for muscle DNA damage analysis. Data are presented as mean ± SEM.