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. 2014 Aug 5;25(11):955–965. doi: 10.1089/hum.2014.048

FIG. 2.

FIG. 2.

Sustained, high-level luciferase expression and resulting immune response. Luciferase activities (p/sec/cm2) are plotted for each of the individual animals from the same groups described in Fig. 1, shown here over the entire 9-month time course of the experiment. (a) C57BL/6 co-injected with pT2/CaL plus SB transposase-encoding plasmid pCMV-SB100X; (b) C57BL/6 injected with pT2/CaL alone; (c) CP immunosuppressed C57BL/6 co-injected with pT2/CaL plus pCMV-SB100X; (d) CP immunosuppressed C57BL/6 injected with pT2/CaL alone; (e) NOD.SCID co-injected with pT2/CaL plus pCMV-SB100X; (f) NOD.SCID injected with pT2/CaL alone. Each line represents an individual mouse, and each point indicates a specific luciferase reading. The black vertical arrow indicates the time at which C57BL/6 mice were challenged with 5 μg pT2/CaL plus 0.5 μg pCMV-SB100X by hydrodynamic injection.