Table 5.
Operating characteristics for novel markers in predicting appendicitis
| Novel marker | Author | Subjects | Cut-off | Sensitivity (%) | Specificity (%) | AUC (Accuracy) | Study type |
|---|---|---|---|---|---|---|---|
| Interleukin 6 | Kharbanda et al.40 (2011) | 280 | 11.3 pg/mL | 82 | 69 | 0.78 | Prospective |
| Paajanen et al.43 (2002) | 80 | 14 pg/mL | 84 | 79 | 0.80 | Prospective | |
| Eriksson et al.58 (1995) | 165 | 15 pg/mL | 66 | 31 | Prospective | ||
| Serum Amyloid A | Lycopoulou et al.60 (2005) | 42 | 45 mg/L | 86 | 83 | 0.96 | Prospective |
| Riboleukograms | Muenzer et al.61 (2010) | 8 | N/A | 80 | 66 | Prospective | |
| Plasma Cytokines | 25 | 100 | |||||
| Granulocyte colony-stimulating factor | Allister et al.62 (2011) | 32 | 28.3 pg/mL | 91 | 56 | 0.76 | Prospective |
| Leucine-rich α-2-glycoprotein in the urine | Kentsis et al.63,64 (2010 and 2012) | 49 | 3.9 ug/mL | 0.99 | Prospective | ||
| Calprotectin (S100A8/A9) | Bealer et al.65 (2010) | 181 | 20 Elisa units | 93 | 54 | 0.71 | Prospective |
| Mills et al.66 (2012) | 843 | 14 Elisa units | 96 | 16 | 0.66 | Prospective |
AUC, area under curve