FIGURE 2.

Schematic for a network screening approach to drug discovery. First, integration of multiscale data sets can be reduced to a minimal gene reporter set specific to a disease of interest, in this case, schizophrenia. Second, expression of this gene reporter set can be used as a platform for high throughput screening of hiPSC neurons generated from schizophrenia patients, in order to identify compounds capable of ameliorating the gene expression signature in patient-derived neurons.