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. 2014 Dec 2;5:461. doi: 10.3389/fphys.2014.00461

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Copyright © 2014 Mamidi, Gresham and Stelzer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of cMyBP-C on length-dependent changes in the magnitude of sudden-stretch induced increase in muscle fiber stiffness (P1). P1 was calculated from the force responses elicited upon a sudden 2% stretch in muscle length imposed on isometrically-contracting ventricular preparations (Stelzer et al., 2006c). Two-Way ANOVA revealed no significant interaction effect and main effects on P1. Post-hoc tests showed that P1 significantly decreased at short SL vs. long SL in WT group but such a trend was absent in KO group. Also, P1 significantly decreased at long SL in KO vs. WT group. Determinations were made from 6 to 13 multicellular preparations and 3 to 4 hearts per each group. Values are reported as mean ± s.e.m. ^*P < 0.05.