Scheme 6. Synthesis of amine 21. (a) CSA, –78 °C, DCM, then O3, then MeOH, Me2S, NaHCO3, to rt; (b) Ti(OiPr)4, MeNH2, EtOH, rt, then NaBH4, 0 °C, 51% over 2 steps.
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