Table I. Phenotypic and Biochemical Characterization of LIRKO mice.

Data were obtained from two- to three-month old male LIRKO mice and their littermate Lox controls on a standard chow diet. Mice were sacrificed in the non-fasted state, at which time serum and liver samples were collected for further analysis. (n=5-8, p<0.05)

	LOX	LIRKO
Weight (g)	32.7 ± 0.8	30.9 ± 0.7
Liver Weight (mg/ g BW)	42.4 ±1.2	27.1 ± 2*
Serum glucose (mg/dL)	132 ± 17	170 ± 32
Serum Insulin (ng/mL)	1.1 ± 0.1	12 ± 3*
FFA (mequiv/L)	0.71 ± 0.60	0.70 ± 0.13
Hepatic Lipids (mg/ g Liver)
Triglycerides	3.58 ± 1.0	4.09 ± 0.8
Total Cholesterol	1.1 ± 0.1	2.1 ± 0.2**
Unesterified Cholesterol	1.0 ± 0.1	1.4 ± 0.1**
Cholesteryl Esters	0.3 ± 0.0	1.3 ± 0.2**