Table 3.
Adverse pregnancy outcomes among women with pregnancy-associated hypertension by presence or absence of abnormal laboratory values
| I (N=1690) | II (N=88) | II. vs I. aOR (95% CI)* | III (N=861) | III. vs I. aOR (95% CI)* | IV (N=113) | IV. vs I. aOR (95% CI)* | |
|---|---|---|---|---|---|---|---|
|
| |||||||
| Composite neonatal morbidity† | 56/1685 (3.3) | 6/88 (6.8) | 2.2 (0.9,5.3) | 56/856 (6.5) | 2.0 (1.4,2.9)+ | 14/111 (12.6) | 4.8 (2.6,9.1)+ |
| RDS | 44/1680 (2.6) | 0/86 (0) | 45/855 (5.3) | 12/111 (10.8) | |||
| Sepsis | 7/1680 (0.4) | 1/86 (1.2) | 8/855 (0.9) | 0/111 (0) | |||
| NEC | 3/1680 (0.2) | 0/86 (0) | 1/855 (0.1) | 3/111 (2.7) | |||
| IVH | 1/1680 (0.1) | 0/86 (0) | 0/854 (0) | 0/111 (0) | |||
| ROP | 2/1680 (0.1) | 0/86 (0) | 4/855 (0.5) | 0/111 (0) | |||
| Apgar ≤3 at 5 min | 11/1687 (0.7) | 5/88 (5.7) | 9/860 (1.0) | 2/112 (1.8) | |||
|
| |||||||
| Fetal or neonatal death (≥20 weeks) | 12/1688 (0.7) | 2/88 (2.3) | 3.6 (0.8,16.8) | 5/857 (0.6) | 0.7 (0.3,2.1) | 2/111 (1.8) | 3.5 (0.7,16.5) |
|
| |||||||
| PTB < 37 weeks | 112/1690 (6.6) | 11/88 (12.5) | 2.1 (1.1,4.0) | 174/861 (20.2) | 3.6 (2.8,4.6)+ | 38/113 (33.6) | 7.8 (5.0,12.1)+ |
|
| |||||||
| PTB < 32 weeks | 10/1690 (0.6) | 2/88 (2.3) | 4.6 (0.96,21.6) | 21/861 (2.4) | 3.8 (1.8,8.1)+ | 11/113 (9.7) | 24.7 (9.9,61.8)+ |
|
| |||||||
| Indicated PTB < 37 weeks | 39/1690 (2.3) | 4/88 (4.5) | 2.0 (0.7,5.9) | 140/861 (16.3) | 8.5 (5.9,12.3)+ | 34/113 (30.1) | 20.1 (12.0,33.9)+ |
|
| |||||||
| Indicated PTB < 32 weeks | 3/1690 (0.2) | 1/88 (1.1) | 7.6 (0.8,75.3) | 18/861 (2.1) | 11.3 (3.3,38.7)+ | 11/113 (9.7) | 82.1 (21.9,307.7)+ |
|
| |||||||
| Placental Abruption | 9/1690 (0.5) | 3/88 (3.4) | 7.1 (1.9,27.5)++ | 9/861 (1.0) | 1.8 (0.7,4.6) | 1/113 (0.9) | 1.7 (0.2,13.8) |
|
| |||||||
| Cesarean Delivery | 494/1690 (29.2) | 40/88 (45.5) | 2.1 (1.3,3.2)++ | 306/861 (35.5) | 1.2 (1.0,1.5) | 51/113 (45.1) | 2.1 (1.4,3.0)+ |
|
| |||||||
| SGA (<5th%) | 96/1682 (5.7) | 5/85 (5.9) | 1.0 (0.4,2.6) | 69/858 (8.0) | 1.5 (1.1,2.0) | 10/112 (8.9) | 1.6 (0.8,3.2) |
|
| |||||||
| NICU Admission | 203/1689 (12.0) | 13/88 (14.8) | 1.3 (0.7,2.4) | 178/860 (20.7) | 1.9 (1.5,2.3)+ | 37/113 (32.7) | 3.9 (2.5,5.9)+ |
|
| |||||||
| Neonatal LOS (days) | 2 [2–3] | 3 [2–4] | ** | 2 [2–4] | ** | 3 [2–5] | ** |
|
| |||||||
| Maternal LOS (days) | 2 [2–3] | 3 [2–4] | ** | 2 [2–3] | ** | 3 [2–4] | ** |
I, Mild hypertension alone; II, Mild hypertension + abnormal laboratory values; III, Severe hypertension alone or any hypertension with severe clinical signs; IV, Severe hypertension alone or any hypertension with severe clinical signs + abnormal laboratory values. Data are n/Total (%) or median [interquartile range]. Boldface indicates p-value <0.05.
Adjusted for maternal age, race, baseline BMI, smoking, treatment group (Vitamin C and E or placebo), education level, & family history of preeclampsia
Adjusted means not reported due to inability to normalize the data
RDS, Sepsis, NEC, IVH (Grade III or IV), ROP, Apgar ≤3 at 5 min
Indicates p-value <0.001
Indicates p-value <0.01