. Author manuscript; available in PMC: 2015 Nov 1.

Published in final edited form as: Rheum Dis Clin North Am. 2014 Sep 2;40(4):581–604. doi: 10.1016/j.rdc.2014.07.002

Table 2.

Studies pertaining to SLC22A12 polymorphisms and effect on serum uric acid and gout.

Study	Population	Polymorphism	Outcome
Iwai, 2004 (39)	Japanese	Multiple missense, nonsense and deletion mutations	Mutations associated with decreased SUA
Taniguchi, 2005 (38)	Japanese	Mutation in exon 4	Alleles associated with decreased SUA and protection from gout
Graessler, 2006 (40)	German	rs3825016 rs7932775 rs11231825 rs11602903	Alleles associated with SUA levels and varying risk for reduced FEUA
Shima, 2006 (121)	Japanese	rs893006	Alleles associated with varying range of SUA levels
Vazquez-Mellado, 2007 (42)	Mexican	Mutations in exon 4 and 5	Mutations found in patients with gout
Jang, 2008 (122)	Korean	rs1529909	Alleles associated with decreased SUA and increased FEUA ^*
Guan, 2009 (123)	Chinese	rs893006	Alleles associated with varying range of SUA levels
Kolz, 2009 (49)	European	rs505802	Alleles associated with decreased SUA
Li, 2010 (41)	Chinese	rs382507 rs57606 rs7932775 rs11231825 rs11602903	Alleles associated with increased SUA
Tu, 2010 (124)	Chinese, Solomon Islanders	rs475688 rs7932775	Alleles associated with increased SUA, gout risk and tophi
Tin, 2011 (59)	African American	rs12800450	Alleles associated with decreased SUA and gout risk
Karns, 2012 (50)	Croatian	rs17300741	Alleles associated with increased SUA

SUA: serum uric acid FEUA: fractional excretion of uric acid

significant association in males only