Figure 4. Effects of CGRP1-37 on cellular apoptosis.
Caspase 3/7 activity from protein extracts that were treated alone with CGRP1-37 or in combination with CGRP8-37, LY294002, Ad.Akt (K179M) and IGF-1. Caspase activity is expressed as relative fluorescence units (RFU). The CGRP1-37 treatment did not directly affect caspase 3/7 activity. The CGRP1-37 + LY294002 and CGRP1-37 + Ad.Akt(K179M) treatments increased caspase 3/7 activity (P<0.05). The IGF-1 + CGRP1-37 treatment had no effect on caspase 3/7 activity (N=3; * P<0.05).