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Pentoxifylline prevents burn-induced intestinal permeability. Intestinal permeability assay to intraluminal 4 kDa FITC-dextran measured 2 hours after severe burn (n ≥ 3 animals per group). Burn injury causes a significant increase in intestinal permeability. Injection with PTX (12.5 mg/kg) immediately after injury attenuates this burn-induced increased in intestinal permeability. *p < 0.01 versus sham and †p < 0.05 versus burn.
