Table 2.
Factors associated with risk of the first cervical HPVI or 6MPI (multivariable Cox proportional-hazards analysis)
| Covariate | Category | HPVI | 6MPI | ||||||
|---|---|---|---|---|---|---|---|---|---|
| No. of women (N = 982) | No. of women with HPVI (N = 496) | HR (95% CI) | p-value | No. of women (N = 982) | No. of women with 6MPI (N = 281) | HR (95% CI) | p-value | ||
| Region | Europe | 644 | 345 | 1 | 644 | 201 | 1 | ||
| Asia Pacific | 168 | 58 | 1.11 (0.81-1.52) | 0.5055 | 168 | 36 | 1.21 (0.78-1.86) | 0.3995 | |
| Latin America | 76 | 46 | 1.16 (0.84-1.60) | 0.3627 | 76 | 24 | 0.99 (0.63-1.57) | 0.9773 | |
| North America | 94 | 47 | 0.88 (0.64-1.20) | 0.4273 | 94 | 20 | 0.75 (0.47-1.20) | 0.2283 | |
| 0.5498 | 0.4934 | ||||||||
| Number of lifetime sexual partners1 | 1 | 800 | 234 | 1 | 800 | 127 | 1 | ||
| 2-3 | 430 | 190 | 4.76 (3.82-5.95) | <0.0001 | 470 | 111 | 4.19 (3.12-5.63) | <0.0001 | |
| ≥4 | 125 | 72 | 19.22 (14.02-26.34) | <0.0001 | 166 | 43 | 14.14 (9.35-21.37) | <0.0001 | |
| <0.0001 | <0.0001 | ||||||||
| History of Chlamydia trachomatis during the past 12 months1 | No | 977 | 463 | 1 | 978 | 257 | 1 | ||
| Yes | 60 | 33 | 3.00 (2.07-4.36) | <0.0001 | 73 | 24 | 2.50 (1.57-4.00) | 0.0001 | |
| <0.0001 | 0.0001 | ||||||||
| Cumulative duration of hormone use for contraception or other indication1 | No use | 804 | 105 | 1 | 804 | 59 | 1 | ||
| 1-12 months | 727 | 173 | 2.18 (1.68-2.83) | <0.0001 | 746 | 111 | 2.10 (1.48-2.98) | <0.0001 | |
| 13-48 months | 536 | 206 | 3.26 (2.45-4.34) | <0.0001 | 590 | 108 | 2.79 (1.91-4.09) | <0.0001 | |
| >48 months | 56 | 11 | 5.42 (2.84-10.36) | <0.0001 | 69 | 2 | 1.62 (0.39-6.74) | 0.5107 | |
| <0.0001 | <0.0001 | ||||||||
| Marital/partner status1 | Living or lived with partner | 238 | 42 | 1 | 271 | 19 | 1 | ||
| Single | 961 | 454 | 1.45 (1.04-2.04) | 0.0291 | 963 | 262 | 1.75 (1.01-3.03) | 0.0445 | |
| 0.0291 | 0.0445 | ||||||||
| Tobacco exposure (number of pack-years)1 | <0.5 | 862 | 402 | 1 | 862 | 223 | 1 | ||
| ≥0.5 | 153 | 94 | 1.17 (0.92-1.47) | 0.1936 | 161 | 58 | 1.22 (0.90-1.66) | 0.2085 | |
| 0.1936 | 0.2085 | ||||||||
| Previous cervical HPV infection1 | No | - | - | - | - | 965 | 231 | 1 | |
| Yes | - | - | - | - | 188 | 38 | 0.49 (0.33-0.72) | 0.0003 | |
| - | 0.0003 | ||||||||
1Time-varying covariates. The number of women represents the number of observations that appeared at least once during the follow-up period. One woman can be counted in several categories. The number of events (HPVI or 6MPI) corresponds to the value recorded at the most recent visit before the endpoint.
Values in italics are the overall p-value.
Age at first sexual intercourse was not included in the multivariable analyses because p-values of >0.2 were obtained in the univariate analyses. The covariates of number of sexual partners during the past 12 months and hormone use or not for contraception or another indication were not included in the multivariable analyses because of overlap with the covariates of number of lifetime sexual partners and cumulative duration of hormone use or other indication, respectively.
6MPI: 6-month persistent HPV infection; CI: confidence interval; HPV: human papillomavirus; HPVI: HPV infection of any duration; HR: Hazard ratio.